Xeomin in Mission Viejo
The bare toxin, purified so nothing rides along with it. Its units convert one-to-one with Botox, which makes it the one honest like-for-like comparison in this category.
Medically reviewed by Lindsay Short, NP-BC, Board-Certified Nurse Practitioner · last reviewed September 2026
What Xeomin costs, and why the comparison is honest
- Xeomin
- Botox
- Daxxify
- Frown lines in Xeomin
Unit counts are typical, not a quote. Yours is agreed before anything is drawn up, and the consultation is free.
Xeomin is priced per unit, and its units convert roughly one-to-one with Botox, which makes it the one honest like-for-like comparison in this category. We agree the count before we start.
- Quoted in writing before anything starts. You hear the full figure at your consultation, not after treatment and not on the day.
- The consultation is free, with no obligation to book and no charge if you decide against it.
- We do not bill insurance. No prior authorization, no coverage denial part-way through, and no treatment decision made by a plan rather than by your clinician.
- Cherry and CareCredit financing are available, and membership pricing is lower than standard rates.
The reason this comparison is worth trusting is that Xeomin units are roughly equivalent to Botox units. That is not true across this category, a Dysport unit does about a third of the work, so its lower per-unit price does not translate into a lower bill. Here it does. Twenty units of Xeomin costs less than twenty units of Botox, for a comparable result.
What the “naked” molecule actually is
Botulinum toxin occurs naturally bundled with a complex of other proteins. They are not what relaxes the muscle; they are packaging. Xeomin is purified so the active molecule arrives on its own.
What that means in the chair: nothing. Onset, duration and result are comparable to Botox, and no patient could tell them apart from the outcome.
What it might mean over a decade: fewer foreign proteins is less material for an immune system to form antibodies against. That is a coherent argument and it is why the product exists.
What it does not mean: that other products cause resistance, or that Xeomin prevents it. True antibody-mediated resistance at cosmetic dosing is uncommon. Most “it stopped working” has a simpler cause, and we would rather find that than sell you a product switch that changes nothing.
“It stopped working”, what we check before switching
This is the most common reason people arrive asking specifically for Xeomin, and in our experience it is usually not antibodies. In order of likelihood:
The dose quietly drifted down
Clinics that price per area have an incentive to use less product over time, and the change is invisible to you because the price did not move. This is the most common explanation by a distance, and it is why we record unit counts and show them to you.
The gaps got longer
Coming in at five months instead of three means living with returning movement for weeks each cycle. The product works exactly as well; you are simply spending more of the year outside its window.
The muscle got stronger
Muscles that are treated inconsistently, long gaps, low doses, keep their bulk and can need more product than they did years ago, not less.
Genuine reduced response
Uncommon, and the diagnosis of exclusion rather than the first assumption. If the first three do not explain it, trying Xeomin is a reasonable and inexpensive next step.
Bring your unit counts if you have them. If you do not, tell us which clinic and what you paid, and we can usually work backwards to whether the dose was the problem.
Where it is used, and how it is dosed
The same areas as any neurotoxin, at effectively the same unit counts as Botox: frown lines 18 to 25 units, forehead 8 to 15, crow’s feet 18 to 24 across both sides. Men typically need more than women in the same area, often around one and a half times.
- Onset
- 3–5 days, real result at 14 days
- Duration
- 3–4 months
- Unit conversion
- About 1:1 with Botox
- Review
- Two weeks, included
Switching from Botox is straightforward and needs no washout. We convert your existing dose rather than restarting, then review at two weeks like any first treatment with a product you have not had here before.
What a year of Xeomin actually costs
Per-unit prices are how this category is advertised and totals are how it is paid for, so it is worth seeing the year rather than the visit. These figures assume a full upper face at typical unit counts, treated three times a year.
| Per unit | Full upper face | Three treatments | |
|---|---|---|---|
| Xeomin | Least expensive per unit | Units convert ~1:1 with Botox | |
| Botox | The reference product | Most studied, most predictable | |
| Daxxify | Same per unit as Botox | Fewer treatments a year |
Two honest observations about that table. Xeomin is the cheapest per treatment, and over a year Daxxify can still come out lower because it removes a visit, the cheapest unit and the cheapest year are not the same product.
And none of it matters if the dose is wrong. A cheaper unit underdosed is worse value than a dearer unit at the right count, which is the whole reason we quote unit counts out loud before we start rather than quoting a price for an area.
Aftercare, and who should not have it
Identical to the rest of the category. Stay upright for four hours, skip the gym that day, and do not rub or massage the treated areas, pressure in those first hours is the only thing likely to move product. Movement softens from day three to five; day fourteen is the result and the review.
Not appropriate during pregnancy or breastfeeding, with a neuromuscular condition such as myasthenia gravis, or after a previous reaction to a botulinum product. Certain antibiotics interact, so bring your medication list. Xeomin contains no cow’s-milk protein, which makes it a straightforward choice for anyone who has to avoid Dysport for that reason.
The neurotoxins page compares all four products, and the Botox page covers unit counts by area in more detail.
Book your free consultationAnswers before you book
How much does Xeomin cost?
The least expensive per unit of the three products we stock. Its units convert roughly one-to-one with Botox units, unlike Dysport, so that lower per-unit price is a genuinely lower treatment cost rather than an artefact of different unit sizes. A twenty-unit frown line therefore costs less here than the same treatment in Botox.
What does "no accessory proteins" actually mean?
Botulinum toxin is naturally bundled with other proteins that do nothing therapeutically. Xeomin is purified so only the active molecule remains, hence "naked" toxin. The practical claim made for this is that fewer foreign proteins means less for your immune system to react to over years of treatment. The claim is reasonable. It is not the same as proven for the average patient.
Does Xeomin prevent resistance to Botox?
That is the marketing version and it overstates the evidence. True antibody-mediated resistance is uncommon at cosmetic doses. What is more common is that treatments seem to stop working as well, which is usually explained by dose drift, longer gaps between visits, or a stronger muscle rather than antibodies. Xeomin is a sensible product to try when it happens. It is not an insurance policy you need to buy up front.
My Botox stopped working as well. Should I switch?
It is worth trying, and worth checking the simpler explanations first. We would look at your unit counts over time, how long you have been leaving between treatments, and whether the muscle has genuinely strengthened. If the dose has quietly drifted down or the gaps have stretched to five months, that is the likely cause and it is fixable without changing product. If none of that explains it, switching to Xeomin is a reasonable next step.
How long does Xeomin last?
Three to four months, the same as Botox. Onset is also comparable at three to five days with the real result at two weeks. In everyday use the two behave very similarly, which is what makes the formulation difference the interesting part rather than the performance.
Do Xeomin units equal Botox units?
Close enough to treat as one-to-one, which is unusual, Dysport does not convert this way. If your frown line has been 20 units of Botox, we would plan around 20 units of Xeomin. That makes switching straightforward and makes the price comparison honest.
Does it need refrigeration?
Not before reconstitution, which is a real difference from the others and matters more to a clinic than to a patient. It has no bearing on your result. We mention it because it occasionally comes up in comparisons as though it were a patient benefit, and it is not.
Who is Xeomin best for?
Three groups: people whose response to other products has genuinely faded over years, people who prefer the simplest possible formulation, and people who want the lowest treatment cost among products whose units compare honestly. For a first-time patient with no history, any of the three we stock is a reasonable start and we would usually begin with Botox.
If your treatments stopped working, start here
A free consultation reviews your unit history and treatment intervals before recommending a product change. Often the fix is dose or timing rather than a different vial, and we would rather find that than sell you a switch.